abstract：:Single-agent bortezomib, a potent, selective, and reversible inhibitor of the 26S proteasome, has demonstrated clinical efficacy in relapsed and refractory mantle cell lymphoma (MCL). Objective response is achieved in up to 45% of the MCL patients; however, complete remission rates are low and duration of response pro...

journal_title：Annals of hematology

authors： Hutter G,Rieken M,Pastore A,Weigert O,Zimmermann Y,Weinkauf M,Hiddemann W,Dreyling M

更新日期：2012-06-01 00:00:00

abstract：:The objective of this study was to investigate whether metabolic tumor volume (MTV) by positron emission tomography (PET) can be a potential prognostic tool when compared with Ann Arbor stage, in stages II and III nodal diffuse large B cell lymphoma (DLBCL). We evaluated 169 patients with nodal stages II and III DLBCL...

journal_title：Annals of hematology

authors： Song MK,Chung JS,Shin HJ,Lee SM,Lee SE,Lee HS,Lee GW,Kim SJ,Lee SM,Chung DS

更新日期：2012-05-01 00:00:00

abstract：:Previous studies have suggested that adherence to imatinib therapy can be an obstacle among patients with chronic myeloid leukemia (CML). We studied adherence to imatinib therapy among CML patients treated at the Sahlgrenska University Hospital. We identified all CML patients that were alive at the 1st of January 2010...

journal_title：Annals of hematology

authors： Jönsson S,Olsson B,Söderberg J,Wadenvik H

更新日期：2012-05-01 00:00:00

abstract：:The somatic mutations of isocitrate dehydrogenase genes (IDH1 and IDH2) have been identified in a proportion of hematologic malignancies. We examined IDH1 R132 and IDH2 R140/R172 mutations by high resolution melting analysis and direct sequencing in Chinese patients with different myeloid malignancies including 198 ac...

journal_title：Annals of hematology

authors： Lin J,Yao DM,Qian J,Chen Q,Qian W,Li Y,Yang J,Wang CZ,Chai HY,Qian Z,Xiao GF,Xu WR

更新日期：2012-04-01 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a rare hematologic malignancy in children. Hyperactivation of the Ras pathway from gene mutations is known to be the key culprit in the development of JMML. In this study, we investigated Ras pathway mutations and prognostic implication in Korean patients with JMML. A total o...

journal_title：Annals of hematology

authors： Park HD,Lee SH,Sung KW,Koo HH,Jung NG,Cho B,Kim HK,Park IA,Lee KO,Ki CS,Kim SH,Yoo KH,Kim HJ

更新日期：2012-04-01 00:00:00

abstract：:The absence of researches about autophagy in multiple myeloma promoted us to explore the biological characteristics and role of autophagy induced by nutrient depletion in multiple myeloma (MM) cell line RPMI8226 cells. Both autophagic and apoptotic morphology were observed by TUNEL, transmission electron microscopy (T...

journal_title：Annals of hematology

authors： Zeng R,He J,Peng J,Chen Y,Yi S,Zhao F,Cui G

更新日期：2012-03-01 00:00:00

abstract：:Controversy remains regarding the transplant outcomes of human leukocyte antigen-identical related bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) for the treatment of patients with hematological malignancies. To provide an estimate of the effect of BMT and PBSCT on clinical ou...

journal_title：Annals of hematology

authors： Chang YJ,Weng CL,Sun LX,Zhao YT

更新日期：2012-03-01 00:00:00

abstract：:Anthracyclines are a major component in the therapy of non-Hodgkin's lymphoma. However, due to their cardiac toxicity potential, curative and palliative treatment is often limited in patients with preexisting cardiac dysfunction. Liposomal doxorubicin formulations have been described to be less cardiotoxic than conven...

journal_title：Annals of hematology

authors： Schmitt CJ,Dietrich S,Ho AD,Witzens-Harig M

更新日期：2012-03-01 00:00:00

abstract：:The prognostic value of cytogenetics in adult acute lymphoblastic leukemia (ALL) is not as established as in childhood ALL. We have analyzed the outcome and prognostic value of karyotype in 84 adults diagnosed with Philadelphia-negative ALL from a single institution that received induction chemotherapy and had success...

journal_title：Annals of hematology

authors： Gómez-Seguí I,Cervera J,Such E,Martínez-Cuadrón D,Luna I,Ibáñez M,López-Pavía M,Gascón A,Roig M,Martínez J,Sanz J,Montesinos P,Martín-Aragonés G,Lorenzo I,Senent L,Barragán E,Cordón L,Sempere A,Sanz GF,Sanz MA

更新日期：2012-01-01 00:00:00

abstract：:We monitored platelet activation by means of P-selectin and platelet monocyte aggregates (PMA) and platelet function by whole blood multiple electrode aggregometry and platelet adhesion under high shear in chronic immune thrombocytopenia patients to define changes in platelet activation during treatment with eltrombop...

journal_title：Annals of hematology

authors： Haselboeck J,Pabinger I,Ay C,Koder S,Panzer S

更新日期：2012-01-01 00:00:00

abstract：:Multiple myeloma (MM) is an incurable disease accompanied by low plasma levels of low-density lipoprotein cholesterol (LDL-c). The significance of altered cholesterol metabolism in the pathophysiology of MM remains elusive. Although it has been hypothesized that myeloma cells depend on exogenous cholesterol for its su...

journal_title：Annals of hematology

authors： Tirado-Vélez JM,Benítez-Rondán A,Cózar-Castellano I,Medina F,Perdomo G

更新日期：2012-01-01 00:00:00

abstract：:In some instances, because of the lack of mass formation and the absence of prominent lymph node enlargement, diagnosis of lymphoma-associated hemophagocytic syndrome (LAHS) is difficult, which results in the development of progressive disease with unfavorable prognosis. Therefore, in the diagnosis of secondary hemoph...

journal_title：Annals of hematology

authors： Tabata C,Tabata R

更新日期：2012-01-01 00:00:00

abstract：:Lower dosage of total body irradiation (TBI) and chemotherapy in reduced-intensity conditioning (RIC) regimens prior to allogeneic stem cell transplantation have reduced the toxicity of the conditioning and non-relapse mortality. The FLAMSA-RIC protocol for high-risk patients with acute myeloid leukemia (AML) and myel...

journal_title：Annals of hematology

authors： Chemnitz JM,von Lilienfeld-Toal M,Holtick U,Theurich S,Shimabukuro-Vornhagen A,Krause A,Brossart P,Hallek M,Scheid C

更新日期：2012-01-01 00:00:00

abstract：:The aim of the present study was to investigate the prognostic role of pre- and/or early post-autologous stem cell transplantation (ASCT) (18)F-flourodeoxyglucose (FDG) positron emission tomography (PET) in patients with relapsed/refractory Hodgkin lymphoma. Forty-three consecutive patients were enrolled in this study...

journal_title：Annals of hematology

authors： Sucak GT,Özkurt ZN,Suyani E,Yaşar DG,Akdemir ÖÜ,Aki Z,Yeğin ZA,Yağci M,Kapucu ÖL

更新日期：2011-11-01 00:00:00

abstract：:von Willebrand disease (VWD) is the commonest inherited bleeding disorder, yet it has not been well recognized in Southeast Asia. The aim of this prospective study was to report our experience of VWD diagnosis and to establish the clinical presentations of VWD in Taiwan. From October 2003 to April 2010, 863 patients w...

journal_title：Annals of hematology

authors： Chen YC,Yang L,Cheng SN,Hu SH,Chao TY

更新日期：2011-10-01 00:00:00

abstract：:Although retreatment with alemtuzumab in relapsing B-cell chronic lymphocytic leukemia (CLL) may be beneficial, there has thus far been no thorough analysis available on this topic. Data were collected from 30 chemotherapy-pretreated patients with progressive CLL who had received alemtuzumab twice in consecutive, dist...

journal_title：Annals of hematology

authors： Fiegl M,Falkner F,Steurer M,Zojer N,Hopfinger G,Haslbauer F,Winder G,Voskova D,Andel J,Lang A,Brychtova Y,Mayer J,Greil R,Gastl G,Austrian Collaborative Study Group on Alemtuzumab in Chronic Lymphocytic Leukemia.,Czech Leuk

更新日期：2011-09-01 00:00:00

abstract：:Polo-like kinase 2 (SNK/PLK2), a transcriptional target for wild-type p53 and is hypermethylated in a high percentage of multiple myeloma and B cell lymphomas patients. Given these data, we sought to study the methylation status of the specific gene in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), a...

journal_title：Annals of hematology

authors： Benetatos L,Dasoula A,Hatzimichael E,Syed N,Voukelatou M,Dranitsaris G,Bourantas KL,Crook T

更新日期：2011-09-01 00:00:00

abstract：:There is increasing evidence for the role of chronic antigenic stimulation (CS) in the development of cancer. Clinical data, however, are rare as is the information on outcome. In this study, the occurrence of chronic infections (CI) and autoimmune diseases (AI) in patients with malignant lymphoma at diagnosis was ass...

journal_title：Annals of hematology

authors： Vanura K,Späth F,Gleiss A,Le T,Porpaczy E,Skrabs C,Hauswirth A,Fleiss K,Wessely F,Gaiger A,Müllauer L,Jäger U

更新日期：2011-08-01 00:00:00

abstract：:Established risk factors for thrombosis in essential thrombocythemia (ET) include age (≥ 60 years) and previous vascular events. Recently, also leukocytosis has been proposed in risk stratification of ET patients. We report a retrospective study on 532 ET patients followed for a median of 7.6 years. Sixty-four patient...

journal_title：Annals of hematology

authors： Palandri F,Polverelli N,Catani L,Ottaviani E,Baccarani M,Vianelli N

更新日期：2011-08-01 00:00:00

abstract：:Hodgkin lymphoma (HL) can be aggressive and intractable in some cases. Patients who relapse after autologous HCT (auto-HCT) have limited treatment options. City of Hope reports our experience in the use of reduced intensity allogeneic hematopoietic cell transplantation (allo-HCT) in 24 heavily pretreated patients with...

journal_title：Annals of hematology

authors： Chen R,Palmer JM,Popplewell L,Shen J,Smith E,Delioukina M,Kogut N,Rosenthal J,Forman S,Nademanee A

更新日期：2011-07-01 00:00:00

abstract：:Recent developments in the field of targeted therapy have led to the discovery of a new drug, plerixafor, that is a specific inhibitor of the CXCR4 receptor. Plerixafor acts in concert with granulocyte colony-stimulating factor (G-CSF) to increase the number of stem cells circulating in the peripheral blood (PB). Ther...

journal_title：Annals of hematology

authors： Basak GW,Knopinska-Posluszny W,Matuszak M,Kisiel E,Hawrylecka D,Szmigielska-Kaplon A,Urbaniak-Kujda D,Dybko J,Zielinska P,Dabrowska-Iwanicka A,Werkun J,Rzepecki P,Wroblewska W,Wiktor-Jedrzejczak W

更新日期：2011-05-01 00:00:00

abstract：:Secondary central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL) includes an isolated CNS relapse or CNS involvement with systemic disease progression. This rare but fatal clinical problem still remains a therapeutic dilemma in the management of DLBCL. However, there are limited data about i...

journal_title：Annals of hematology

authors： Kim SJ,Oh SY,Kim JS,Kim H,Lee GW,Won JH,Shin HJ,Yang DH,Choi CW,Park J,Kim WS,Suh C

更新日期：2011-05-01 00:00:00

abstract：:Indolent primary cutaneous B cell lymphomas (PCBCL) generally have a good prognosis, but they often relapse leading in some cases to extracutaneous disease and therefore, to poor survival. We developed a prognostic model to improve the therapeutic approach to these lymphomas. Two hundred and seventeen patients with di...

journal_title：Annals of hematology

authors： Mian M,Marcheselli L,Luminari S,Federico M,Cantonetti M,Sarris AH,Rossi A,Rambaldi A,Frontani M,Devizzi L,Gianni AM,Busetto M,Berti E,Martinelli G,Tsang RW,Ferreri AJ,Pinotti G,Pogliani E,Zucca E,Cortelazzo S

更新日期：2011-04-01 00:00:00

abstract：:The microRNA/miR deregulation in BCR-ABL-negative myelodysplastic-myeloproliferative neoplasms (MDS/MPN) is not known. Myelopoiesis-associated miR-10a, miR-17-5p, miR-155, miR-223 and miR-424 were analysed by real-time polymerase chain reaction (PCR) in bone marrow cells of atypical chronic myeloid leukaemia (aCML, n ...

journal_title：Annals of hematology

authors： Hussein K,Büsche G,Muth M,Göhring G,Kreipe H,Bock O

更新日期：2011-03-01 00:00:00

abstract：:We conducted a nationwide cohort study of adult Danish patients with primary chronic immune thrombocytopenia (cITP) to examine selected patient and clinical characteristics as predictors for splenectomy. We analyzed data from the Danish National Patient Registry and patient medical records from 1996 to 2007. Using Cox...

journal_title：Annals of hematology

authors： Jensen AO,Nørgaard M,Engebjerg MC,Farkas DK,Fryzek JP,Zhao S,Sørensen HT

更新日期：2011-02-01 00:00:00

abstract：:Defects in central and peripheral tolerance are thought to contribute to life-threatening graft-versus-host disease (GvHD), a severe complication following allogeneic stem cell transplantation (SCT). Recent investigations have demonstrated regulatory T cells (Tregs) to suppress allogeneic immune reactions. Therefore, ...

journal_title：Annals of hematology

authors： Ukena SN,Grosse J,Mischak-Weissinger E,Buchholz S,Stadler M,Ganser A,Franzke A

更新日期：2011-02-01 00:00:00

abstract：:Bleomycin-induced pneumonitis (BIP) has been well described in Hodgkin's lymphoma (HL) patients. The impact of BIP on patients uniformly treated with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) is not clear; previous studies have included patients treated with both ABVD and hybrid regimens. We reviewed ...

journal_title：Annals of hematology

authors： Ngeow J,Tan IB,Kanesvaran R,Tan HC,Tao M,Quek R,Lim ST

更新日期：2011-01-01 00:00:00

abstract：:Over 80% of the α-thalassemia cases in southern China are caused by large deletions involving the α-globin gene cluster on chromosome 16p13.3. Here, we characterized a novel 27.6-kb deletion on the α-globin gene cluster in a Chinese family. Its breakpoints were detected to lie between coordinates 9079 and 36718 of the...

journal_title：Annals of hematology

authors： Wei XF,Shang X,He DQ,Huang JW,Zhang XH,Xu XM

更新日期：2011-01-01 00:00:00

abstract：:Although B chronic lymphocytic leukemia (B-CLL) cells express the alpha chain of the interleukin-2 (IL-2) receptor CD25, little is known about the effect of IL-2 on apoptosis in B-CLL cells. We have shown previously that stimulation of B-CLL cells with a CpG-oligonucleotide induces IL-2 high affinity receptors. In our...

journal_title：Annals of hematology

authors： Decker T,Bogner C,Oelsner M,Peschel C,Ringshausen I

更新日期：2010-11-01 00:00:00

abstract：:We conducted a phase 2 study with bortezomib, doxorubicin, and dexamethasone (PAD) followed by thalidomide and dexamethasone (TD) in patients with relapsed multiple myeloma (MM). Forty patients were enrolled between November 2005 and October 2007, with follow-up continuing until January 2009. Efficacy could be assesse...

journal_title：Annals of hematology

authors： Lee SS,Suh C,Kim BS,Chung J,Joo YD,Ryoo HM,Do YR,Jin JY,Kang HJ,Lee GW,Lee MH,Shim H,Kim K,Yoon SS,Bang SM,Kim HY,Lee JJ,Park J,Lee DS,Lee JH,Korean Multiple Myeloma Working Party.

更新日期：2010-09-01 00:00:00

abstract：:Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption. Dietary quality, alcoholism and other life-style factors can increase the risk of iron overload, especially among genetically at risk p...

journal_title：Annals of hematology

authors： Aranda N,Viteri FE,Montserrat C,Arija V

更新日期：2010-08-01 00:00:00

abstract：:The rarity of severe complications of this disease in children makes randomized clinical trials in immune thrombocytopenia (ITP) unfeasible. Therefore, the current management recommendations for ITP are largely dependent on clinical expertise and observations. As part of its discussions during the Intercontinental Coo...

journal_title：Annals of hematology

authors： Tamary H,Roganovic J,Chitlur M,Nugent DJ

更新日期：2010-07-01 00:00:00

abstract：:Hematopoietic recovery after high-dose chemotherapy (HDC) in the treatment of hematological diseases may be slow and/or incomplete. This is generally attributed to progressive hematopoietic stem cell failure, although defective hematopoiesis may be in part due to poor stromal function. Chemotherapy is known to damage ...

journal_title：Annals of hematology

authors： Kemp K,Morse R,Wexler S,Cox C,Mallam E,Hows J,Donaldson C

更新日期：2010-07-01 00:00:00

abstract：:The aim of this phase IV study was to (1) to define efficacy of escalating dose imatinib in chronic myeloid leukemia (CML) patients showing suboptimal response to standard dose imatinib and (2) to find markers that predict the response to escalating doses of imatinib. CML patients in chronic phase (CP) who failed to a...

journal_title：Annals of hematology

authors： Koh Y,Kim I,Yoon SS,Kim BK,Kim DY,Lee JH,Lee KH,Park E,Kim HJ,Sohn SK,Joo YD,Kim SJ,Chung J,Shin HJ,Kim SH,Kim CS,Song HS,Kim MK,Hyun MS,Ahn JS,Jung CW,Park S,Korean Society of Hematology CML working party.

更新日期：2010-07-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is characterised by a transient or persistent decrease in platelets accompanied by an increased risk of bleeding, which can have a significant negative impact on patients' health-related quality of life. The condition has long been associated with an increased rate of immune-mediated plat...

journal_title：Annals of hematology

authors： Kühne T,Imbach P

更新日期：2010-07-01 00:00:00

abstract：:While much has been learned about the basic immunology and clinical characteristics of immune thrombocytopenia, many important questions remain with regard to pathogenesis, disease progression, identification of novel therapeutic targets and approaches, and clinical trials that rationalize and optimize use of existing...

journal_title：Annals of hematology

authors： Zehnder JL,Semple JW,Imbach P,Neufeld EJ,Buchanan GR,Cines DB,ICIS Study Group on Future Research in ITP.

更新日期：2010-07-01 00:00:00

abstract：:It has been suggested that Asian and Western myelodysplastic syndrome (MDS) patients have different cytogenetic and prognostic features. In this study, we retrospectively analyzed clinical and cytogenetic data from 435 Chinese adult primary MDS patients. In addition, we evaluated the prognostic value of the World Heal...

journal_title：Annals of hematology

authors： Wang H,Wang X,Xu X,Lin G

更新日期：2010-06-01 00:00:00

abstract：:Systemic AL amyloidosis is associated with nearly 15% of cases of multiple myeloma, but data on the frequency and significance of amyloid deposits in the bone marrow of patients affected by multiple myeloma without clinical signs of systemic amyloidosis are scanty. Bone marrow smears of 166 unselected patients affecte...

journal_title：Annals of hematology

authors： Petruzziello F,Zeppa P,Catalano L,Cozzolino I,Gargiulo G,Musto P,D'Auria F,Liso V,Rizzi R,Caruso N,Califano C,Piro E,Musso M,Bonanno V,Pia Falcone A,Tafuto S,Di Raimondo F,De Laurentiis M,Pane F,Palombini L,Rotoli

更新日期：2010-05-01 00:00:00

abstract：:To characterize T-cell large granular leukemia in Asia, 22 Chinese patients from a single institute were reported, together with an analysis of 88 Asian and 272 Western patients identified from the literature. In our cohort, anemia due to pure red cell aplasia (PRCA) occurred in 15/22 (68%) of cases, being the most co...

journal_title：Annals of hematology

authors： Kwong YL,Au WY,Leung AY,Tse EW

更新日期：2010-04-01 00:00:00

abstract：:This study aimed to determine whether dose-dense therapy improves 3-year survival over the standard therapy for untreated aggressive lymphoma. One hundred and fifteen patients with untreated aggressive lymphoma were stratified by center, age, and international prognostic index and randomized to one of two treatment ar...

journal_title：Annals of hematology

authors： Fridrik MA,Hausmaninger H,Lang A,Drach J,Krieger O,Geissler D,Michlmayr G,Ulsperger E,Chott A,Oberaigner W,Greil R

更新日期：2010-03-01 00:00:00